Introduction
As most human orofacial infections originate from odontogenic infections, antibiotic prescription is important in dental follow.1 Nevertheless, the misuse of antibiotics in numerous medical fields, together with dentistry, has led to antibiotic-resistant bacterial species.2 Antimicrobial resistance is a critical scientific downside and poses dangers to sufferers and future populations.3 It’s predicted that multidrug-resistant infections will end in 1000’s of deaths yearly, with substantial financial impacts.4 Though the speed of antibiotic prescription by dentists will not be similar to that by physicians, the position of dentists within the injudicious prescription of sure antibiotics is appreciable.5
In dentistry, antibiotics can be utilized prophylactically throughout invasive endodontic surgical procedures for sufferers discovered to have particular well being situations in a danger evaluation.6,7 Antibiotics are additionally utilized in particular conditions, resembling for dental infections with systemic involvement7–10 and acute apical abscesses in medically compromised sufferers.7,10 Nevertheless, many endodontic situations might be managed with native measures, with out antibiotics.8,9,11 The suitable use of antibiotics for endodontic remedy requires an understanding of the endodontic-disease therapy processes and the bacterial species answerable for the an infection. Antibiotics ought to be used solely when required for particular circumstances; when there isn’t a bacterial invasion of the basis canal system throughout reversible or irreversible pulpitis, for example, antibiotics are usually not required.12
In Saudi Arabia, a number of research have been carried out to evaluate dentists’ consciousness of the existence of antibiotic prescription tips and indications for endodontic remedy. In a single research, 65.9% of the individuals didn’t comply with any particular guideline and ceaselessly prescribed antibiotics in conditions the place this was neither needed nor indicated.13 These earlier research focused normal dentists and targeted on particular cities across the nation. Nevertheless, it will even be helpful to match dental interns’ (DIs) information of the antibiotic prescription tips and indications to that of normal dental practitioners (GDPs) to find out if the dental undergraduate curriculum must be up to date to account for the brand new antibiotic prescription tips. The potential for indiscriminate antibiotic prescription by dentists might be larger in sure international locations, resembling Saudi Arabia, by which there are few restrictions to dentists’ antibiotic prescription. The present suggestions for antibiotic prescription in endodontics are guided by specialist endodontic associations such because the American Affiliation of Endodontists and the European Society of Endodontology (ESE) and dental our bodies such because the Scottish Dental Scientific Effectiveness Programme. There’s a consensus that the native therapy measures (ie, caries excavation or restoration, pulpotomy, pulpectomy, surgical incision, drainage of soft-tissue swellings, and extraction) are ample to comprise endodontic infections.7–11
DIs are of their remaining phases of coaching and can quickly be certified to begin their scientific follow as GDPs, which signifies that they are going to have the ability to prescribe antibiotics independently, with out requiring their supervisors’ enter. In addition to, DIs can already present proof of what they’ve realized and assimilated throughout their training, which they are going to apply to their skilled follow. Alternatively, GDPs are professionals subjected to numerous environmental components, resembling time stress whereas seeing their sufferers, which has been described as an element contributing to inappropriate antibiotic prescriptions.14 Subsequently, this research aimed to guage the views of the DIs and GDPs within the Asir area of Saudi Arabia on antibiotic prescription for endodontic situations. The null speculation for this research was that there isn’t a statistical distinction between the views of the DIs and GDPs within the Asir area of Saudi Arabia on antibiotic prescription for endodontic situations.
Supplies and Strategies
The conduct of this research was permitted by the Institutional Evaluate Board of King Khalid College, Faculty of Dentistry KKUCOD (Approval No. IRB/KKUCOD/ETH/2020-21/017). A web-based survey was performed, with the questionnaire consisting of general-knowledge questions on antibiotics and scientific vignettes the place the individuals had been requested to point whether or not there’s a want for antibiotic prescription or there may be none.
The questionnaire was developed following the Guidelines for Reporting Outcomes of Web E-Surveys (CHERRIES)15 (see Appendix 1). A complete of 120 on-line survey participation invites had been despatched to 2 teams: group 1 (G1) consisting of the DIs on the Faculty of Dentistry of King Khalid College (n = 60) and group 2 (G2) consisting of GDPs within the governmental sector throughout the area of Asir, Saudi Arabia (n = 60). The invites had been despatched individually through the Dental Internship Committee at KKUCOD for G1 and the Basic Directorate of Well being Affairs of the Asir area for G2. The net survey was made accessible from October 30, 2020, to November 30, 2020, and reminders had been despatched weekly to the invitees after the survey was launched.
The questionnaire consisted of 16 qualitative and quantitative questions (Appendix 2). The primary 10 questions requested about normal info relating to the individuals, resembling the faculty of dentistry the place they graduated, occupation, years of expertise, variety of emergency sufferers seen per day, frequency of antibiotic prescription for every working day, and consciousness of the existence of antibiotic prescription tips for endodontic remedy. The remaining six questions included scientific vignettes, the place the individuals had been requested to state whether or not they would or wouldn’t prescribe antibiotics in every of the circumstances. The right solutions had been based mostly on the out there antibiotic prescription tips,8–10 (Appendix 2).
Survey Design
The net survey questionnaire was constructed by the analysis staff (consisting of an academician/endodontist advisor and two normal dentists with 10 years’ expertise), counting on earlier research associated to the subject.16,17 It was piloted with two DI and two GDP individuals for validation functions. The questionnaire consisted of three important pages, as described beneath.
Web page 1
- “Contributors’ info sheet (PIS)” was the primary web page of the web survey questionnaire. It included all the data that the individuals wanted to know as regards the research, such because the research title and targets and the researchers’ contact particulars.
- The “Consent Type” adopted, which included three obligatory questions with “Sure” or “No” response choices, as proven beneath.
- I perceive that my participation is voluntary and that I’m free to withdraw at any time, with out giving any motive for such.
- I agree to participate on this research.
- I perceive that the researchers intend to publish the outcomes of this research in a scientific manuscript and/or poster, the place all of the revealed knowledge will likely be nameless, and the research individuals is not going to be recognized.
Web page 2: Titled “Questionnaire,” it contained general-information questions.
Web page 3: Titled “Questionnaire,” it contained the clinical-vignette gadgets.
Information Evaluation
All the information had been collected anonymously and had been proven as categorical variables (n; % of the individuals). The inter-group statistical comparisons of the specific variables’ distributions had been examined utilizing the chi sq. check or the Fisher’s actual likelihood check if greater than 20% of the cells had an anticipated frequency of lower than 5. P-values < 0.05 had been thought of statistically vital. All the information had been statistically analyzed utilizing Statistical Bundle for Social Sciences (SPSS model 22.0, IBM Company, USA) for MS Home windows.
Outcomes
A complete of 88 responses had been acquired (from 50 of the 60 DIs in G1 [83.3%] and from 38 of the 60 GDPs in G2 [63.33%]). Table 1 reveals a abstract of the responses to questions 1–9 (Q1–9). In regard to the distribution of the variety of endodontic emergency sufferers seen per day, it differed considerably between G1 and G2 (p < 0.05), with a considerably larger variety of endodontic emergency sufferers seen per day by the G2 individuals.
![]() |
Desk 1 Basic Abstract of the Solutions of the Dental Interns and Basic Dental Practitioners in This Research to Questions 1–9 |
For Q5, the distribution of the speed of antibiotic prescription for endodontic issues didn’t differ considerably between G1 and G2 (p > 0.05). For Q6, the distribution of opinions relating to the situations for which antibiotics shouldn’t be prescribed (eg, symptomatic reversible pulpitis, symptomatic irreversible pulpitis, persistent apical periodontitis) didn’t differ considerably between G1 and G2 (p > 0.05 for all). Nevertheless, the distribution of opinions relating to the situations for which antibiotics ought to be prescribed (eg, symptomatic apical periodontitis, acute apical abscess, and systemic issues) considerably differed between the 2 teams (p < 0.05 for all). A considerably larger proportion of G1 individuals than G2 individuals cited “systemic issues” (the right reply) as a situation for which antibiotics ought to be prescribed (p < 0.05).
For Q7, the distribution of the notice of the existence of antibiotic prescription tips for endodontic situations didn’t differ considerably between G1 and G2 (57.9% vs 56.0%; p > 0.05). The distinction was statistically insignificant as nicely for Q8 and Q9 (p > 0.05).
Within the evaluation of the individuals’ solutions to the scientific vignettes (Q11–16, Figures 1 and 2), it was discovered that the distribution of responses relating to antibiotic use didn’t differ considerably between G1 and G2 (p > 0.05).
Dialogue
This research aimed to evaluate the views of the DIs on the Faculty of Dentistry of King Khalid College and of the GDPs throughout the Asir area of Saudi Arabia on antibiotic indications for endodontic remedy through a web based survey. Total, the outcomes point out no statistically vital distinction between the DIs and GDPs. This research end result differs from these of the research by Martin-Jimenez et al16 and Al Masan et al17 which investigated the identical subject. The doable clarification of this distinction is that this research’s pattern included DIs and GDPs whereas the 2 aforementioned research concerned undergraduate dental college students. Many of the individuals in each teams on this research had been conscious that there have been out there antibiotic prescription tips in endodontics, however lower than half of them had learn such tips. Each teams had been conscious of the results of the overuse of antibiotics, resembling world antibiotic resistance, with no vital distinction between the DIs and the GDPs (71.1% vs 80.0%; p > 0.05). There was additionally no vital distinction between the teams’ attitudes towards antibiotic prescription by scientific expertise, opposite to the research by Al Masan et al17 and just like the research by Al-Huwayrini et al.18 The doable clarification of that is that each teams on this research had been holding themselves up to date relating to the aforementioned tips.
Piloting a questionnaire provides an early indication of the revisions that must be made within the questions, though it doesn’t make sure the definitive success of the research.19 A pilot research was thus performed earlier than the questionnaire was distributed to the individuals. The survey questionnaire was piloted with two DIs and two GDPs to validate the questions. Though the variety of individuals within the pilot stage was low, this was non-consequential as a result of this stage simply aimed to find out if there was a must revise the questions.19 The purpose of piloting was achieved as many feedback relating to the define of the questions and the font that was used had been obtained therefrom. The required minimal response charge will not be clearly mirrored within the literature, however a 70–80% response charge is taken into account sufficient by some authors to exclude non-response bias.20,21 This research’s response charge was similar to these of the earlier research within the literature.10,17,22–24 Response charges might differ resulting from components such because the questionnaire subject, the distinction between the respondents and the non-respondents, the pattern choice and dimension, the focused group sort, the questionnaire design, and the distribution technique used.25 On this research, the response charges remained extraordinarily low till the DIs had been approached throughout their scientific periods; the researchers e-mailed the teams’ representatives, asking them to encourage their fellow DIs to take part within the research. Though this technique was time consuming, its impact was noticeable because the response charge elevated from 20% on the opening of the survey to 83.3% on the time that the survey closed, which has similarities to the response charges obtained by Al Masan et al.17 Barclay et al26 and Nulty et al.27 The impact of reminders on growing the response charge, nonetheless, is controversial within the literature; some endorse its effectiveness26,27 whereas others don’t.28 On this research, a small proportion of the individuals in each teams said that they’d by no means prescribe antibiotics for endodontic situations (Q6). This may very well be as a result of such individuals misunderstood the query or lacked information concerning the matter. Though the native dental therapy measure is ample to handle an acute apical abscess and there’s no must prescribe antibiotics,7–10 a excessive proportion of the individuals in each teams (G1 = 54%, G2 = 76.3%) said that acute apical abscess was a sign for antibiotic prescription (Q7). This development of overusing antibiotics for treating this situation was in settlement with the outcomes obtained by Martin-Jimenez et al16 and Al Masan et al.17
The clinical-vignette gadgets (Q11–16) had been designed to mirror controversial scientific situations with quite a lot of scientific shows. The questions and solutions had been designed to incorporate each quantitative knowledge (as choices: antibiotics indicated or no antibiotics indicated) and qualitative knowledge (an area was offered for the individuals to justify their solutions). The right solutions for Q11–15 was that antibiotic prescription will not be indicated, however that for Q16 was that antibiotic prescription is indicated. The vast majority of the individuals in each teams (G1 = 50%, G2 = 57.9%) wouldn’t prescribe antibiotics to deal with tooth with necrotic pulp tissue and symptomatic apical periodontitis (Q11), which is in distinction to the outcomes obtained by Martin-Jimenez et al16 and Al Masan et al.17 Nevertheless, non-negligible percentages of the individuals in each teams on this research (G1 = 42%, G2 = 36.8%) would prescribe antibiotics for such circumstances. The doable clarification of those excessive percentages (albeit not the bulk) is that the individuals may need understood {that a} affected person’s “feeling feverish” was a sign of systemic involvement. Certainly, a number of individuals justified their solutions by stating that the affected person had fever, which is taken into account an indication of systemic involvement. The phrase feverish was added to evaluate the individuals’ means to evaluate systemic issues because the time period systemic issues might be imprecise.9 Therefore, clinicians ought to use an goal technique of assessing such issues to keep away from overusing antibiotics for such circumstances.29
In a scientific vignette of failed root canal therapy (Q12), the usage of antibiotics related to localized signs with out systemic issues will not be indicated.10 The vast majority of the individuals in each teams wouldn’t prescribe antibiotics for such circumstances (G1 = 72%, G = 57.9%). A number of individuals justified their reply that there’s a want for antibiotic prescription in such case by stating that ache is current and it must be relieved earlier than beginning secondary root canal therapy, and that antibiotics should be prescribed to have the ability to give sufficient native anesthesia. Ache was highlighted in a earlier research as an element influencing GDPs’ antibiotic prescription.14 Nevertheless, there may be accumulating proof that there are various efficient measures to regulate ache, resembling offering analgesics and native therapy with out the necessity for antibiotic prescription.30–34 Q13 aimed to evaluate the individuals’ up to date information of the brand new tips on antibiotic prophylactic use for sufferers with a historical past of rheumatic fever and with a analysis of necrotic pulp with asymptomatic apical periodontitis. On this scientific vignette, the affected person’s historical past indicated the incidence of rheumatic fever 28 years in the past. Based on the Nationwide Institute for Well being and Care Excellence tips and newest overview updates6 and the most recent ESE7 place assertion for antibiotics utilized in endodontics, antibiotic prophylaxis will not be indicated for such situation throughout dental therapy. Roughly half of the G1 individuals and 73.3% of the G2 individuals wouldn’t prescribe antibiotics for such circumstances. The individuals who would prescribe antibiotics regardless of the most recent tips justified their reply that antibiotics ought to be prescribed in such case by stating that antibiotic prescription in such case is a prophylactic measure as a result of the historical past of rheumatic fever is taken into account a high-risk situation.6,7
Failure to attain profound native anesthesia will not be a sign for antibiotic prescription (Q14), however 10% of the G1 individuals and 13% of the G2 individuals would prescribe antibiotics in circumstances the place native anesthesia was not efficient, with out giving any motive for his or her reply. Among the many perceived causes of failed native anesthesia are the presence of accent nerves, ion trapping, nervousness, and central core idea.35 The right strategy in such circumstances is to make use of various methods for attaining native anesthesia.36 Q15 described a affected person who had poorly managed diabetes, with indicators and signs of persistent apical periodontitis. Fifty-four % of the G1 individuals and 57.9% of the G2 individuals favored antibiotic use in such case, which isn’t the right reply. Antibiotics are usually not required for persistent apical abscess with out systemic involvement. A patent sinus tract gives steady drainage; apart from, no systemic involvement was introduced within the scientific vignette. Ideally, native measures resembling initiation of major root canal therapy should be resorted to, with doable affected person recommendation to make use of post-operative analgesic for ache management. The truth that the affected person is diabetic and that his diabetes standing is poorly managed doesn’t point out antibiotic prescription to regulate the endodontic situation. Somewhat, it signifies the necessity for liaising with the affected person’s medical doctor to regulate his diabetic standing.37 Q16 was the one scientific vignette the place the usage of antibiotics was indicated due to the indicators of spreading an infection, danger of cellulitis, and related danger of an infection in harmful areas, which may have an effect on the very important physique capabilities, resembling respiration.7–9 Sixty-two % of the G1 individuals and 55.3% of the G2 individuals would prescribe antibiotics in such case, however 30% of the G1 individuals and 34.5% of the G2 individuals wouldn’t and justified their reply by stating that root canal therapy and day by day monitoring of this example are sufficient to handle such case.
The net administration of survey questionnaires has many obvious benefits and is growing in reputation. On-line surveys are economical, straightforward to entry, fast, and environment friendly strategies of accumulating knowledge.38–40 One of many essential moral benefits of utilizing a web based survey software program software is that the respondents can’t be traced. There’s additionally no want to make use of e-mail addresses, and there’s a decrease chance of invading the respondents’ privateness. Nevertheless, as it isn’t doable to confirm the respondents’ id in any approach, the individuals who ought to be excluded from the survey (within the present research, undergraduate dental college students) might find yourself being included within the survey. The researcher has solely minimal management over the respondents’ entry to and engagement with the fabric. This can be thought of one of many limitations of this research as the information might have been contaminated if the excluded inhabitants had entry to and accomplished the questionnaire. As well as, the questionnaire technique of accumulating knowledge for analysis functions obtains solely a “snapshot” of the individuals’ information degree on the time that they took the survey. The identical cohort of individuals was not adopted up over time, and as such, their profession progress was not accounted for. One other limitation of this research was its small focused pattern dimension. As the present research was restricted to at least one area in Saudi Arabia, there was a restricted variety of individuals in each teams that may very well be included. This may need affected the exterior validity of this research and its means to characterize these two teams everywhere in the nation. Nevertheless, it should be famous that though the focused pattern dimension was small, the response charge of this research was similar to these of the earlier related research within the literature.17,22–25
This research’s outcomes may very well be attributed to the present bachelor dental applications in Saudi Arabia. Dental college students are sometimes uncovered to oral-infection situations, and their scientific use of antibiotics for such circumstances with inadequate information of the rules relating to their use will have an effect on their administration of the affected person’s dental situation. Moreover, providing persevering with dental training programs offering correct and up-to-date information on this subject might assist enhance the usage of antibiotics for endodontic situations.
Conclusion
This research revealed that each the DI and GDP individuals might prescribe antibiotics for endodontic situations the place they don’t seem to be indicated. Additional research together with a bigger pattern, a wider geographical area, and totally different schools of dentistry inside Saudi Arabia can present higher concepts of the explanations behind the misuse of antibiotics for endodontic situations.
Ethics and Consent
On this research, all individuals had been offered knowledgeable consent in accordance with the Declaration of Helsinki.
Disclosure
The authors report no conflicts of curiosity for this work.
References
1. Dar-Odeh NS, Abu-Hammad OA, Al-Omiri MK, Khraisat AS, Shehabi AA. Antibiotic prescribing practices by dentists: a overview. J Ther Clin Threat Handle. 2010;6:301–306. doi:10.2147/TCRM.S9736
2. Ventola CL. The antibiotic resistance disaster: half 1: causes and threats. Pharmacol Ther. 2015;40:277.
3. Davies SC, Fowler T, Watson J, Livermore DM, Walker D. Annual report of the chief medical officer: an infection and the rise of antimicrobial resistance. Lancet. 2013;381:1606–1609.
4. O’Neill J. Tackling Drug-Resistant Infections Globally: Remaining Report and Suggestions. London: Wellcome Belief & HM Authorities; 2016.
5. Halboub E, Alzaili A, Quadri MFA, Al-Haroni M, Al-Obaida MI, Al-hebshi NN. Antibiotic prescription information of dentists in Kingdom of Saudi Arabia: a web based, country-wide survey. J Contemp Dent Pract. 2016;17(3):198–204. doi:10.5005/jp-journals-10024-1827
6. Nationwide Institute for Well being and Care Excellence. Prophylaxis in opposition to infective endocarditis: antimicrobial prophylaxis in opposition to infective endocarditis in adults and youngsters present process interventional procedures; 2016. Obtainable from https://www.nice.org.uk/guidance/cg64.
7. Segura‐Egea JJ, Gould Ok, Hakan Şen B; European Society of Endodontology. European Society of Endodontology place assertion: the usage of antibiotics in endodontics. Int Endod J. 2018;51:20–25. doi:10.1111/iej.12781
8. Scottish Dental Scientific Effectiveness Programme. Drug prescribing for dentistry, dental scientific steerage; 2011. Obtainable from: https://www.sdcep.org.uk/published-guidance/drug-prescribing/.
9. American Affiliation of Endodontists. Antibiotics: a dangerous prescription; 2016. Obtainable from https://www.aae.org/specialty/communique/antibiotics-a-risky-prescription/.
10. Segura-Egea JJ, Gould Ok, Hakan-Sen B, et al. Antibiotics in endodontics: a overview. Int Endod J. 2017;50:1169–1184. doi:10.1111/iej.12741
11. Sharif F. Antimicrobial Prescribing for Basic Dental Practitioners. London, UK: College of Basic Dental Apply (UK); 2015.
12. Haapasalo M, Endal U, Zandi H, Coil JM. Eradication of endodontic an infection by instrumentation and irrigation options. Endod Subjects. 2005;10:77–102. doi:10.1111/j.1601-1546.2005.00135.x
13. Al-Johani Ok, Reddy SG, Al Mushayt AS, El-Housseiny A. Sample of prescription of antibiotics amongst dental practitioners in Jeddah, KSA: a cross-sectional survey. Niger J Clin Pract. 2017;20:804–810.
14. Cope AL, Francis NA, Wooden F, Chestnutt IG. Antibiotic prescribing in UK normal dental follow: a cross-sectional research. Neighborhood Dent Oral Epidemiol. 2015;44:145–153. doi:10.1111/cdoe.12199
15. Eysenbach G. Bettering the standard of net surveys: the Guidelines for Reporting Outcomes of Web E-Surveys (CHERRIES) [published correction appears. J Med Internet Res. 2004;6(3):e34. doi:10.2196/jmir.6.3.e34
16. Martin-Jimenez M, Martin-Biedma B, Lopez-Lopez J, et al. Dental students’ knowledge regarding the indications for antibiotics in the management of endodontic infections. Int Endod J. 2018;51:118–127. doi:10.1111/iej.12778
17. Al Masan AA, Dummer PMH, Farnell DJJ, Vianna ME. Antibiotic prescribing for endodontic therapies: a comparative survey between general dental practitioners and final year Bachelor of Dental Surgery students in Cardiff, UK. Int Endod J. 2018;51:717–728. doi:10.1111/iej.12887
18. Al-Huwayrini L, Al-Furiji S, Al-Dhurgham R, Al-Shawaf M, Al-Muhaiza M. Knowledge of antibiotics among dentists in Riyadh private clinics. Saudi Dent J. 2013;25(3):119–124. doi:10.1016/j.sdentj.2013.05.001
19. Van Teijlingen E, Hundley V. The importance of pilot studies. Nurs Stand. 2002;16:33–36. doi:10.7748/ns2002.06.16.40.33.c3214
20. Evans SJ. Good surveys guide. Br Med J. 1991;302:302–303. doi:10.1136/bmj.302.6772.302
21. Christie D, Gordon I, Heller RF. Epidemiology: An Introductory Text for Medical and Other Health Science Students. Sydney, Australia: UNSW Press; 1997.
22. Palmer NAO, Pealing R, Ireland RS, Martin MV. Therapeutics: a study of prophylactic antibiotic prescribing in National Health Service general dental practice in England. Br Dent J. 2000;189:43–46. doi:10.1038/sj.bdj.4800597
23. Rodriguez-Nunez A, Cisneros-Cabello R, Velasco-Ortega E, Llamas-Carreras JM, Torres-Lagares D, Segura-Egea JJ. Antibiotic use by members of the Spanish Endodontic Society. J Endod. 2009;35:1198–1203. doi:10.1016/j.joen.2009.05.031
24. Cunningham CT, Quan H, Hemmelgarn B, et al. Exploring physician specialist response rates to web-based surveys. BMC Med Res Methodol. 2015;15:32. doi:10.1186/s12874-015-0016-z
25. Parashos P, Morgan MV, Messer HH. Response rate and non-response bias in a questionnaire survey of dentists. Community Dent Oral Epidemiol. 2005;33:9–16. doi:10.1111/j.1600-0528.2004.00181.x
26. Barclay S, Todd C, Finlay I, Grande G, Wyatt P. Not another questionnaire! Maximizing the response rate, pre-predicting non-response, and assessing non-response bias in postal questionnaire studies of GPs. Fam Pract. 2002;19:105–111. doi:10.1093/fampra/19.1.105
27. Nulty DD. The adequacy of response rates to online and paper surveys: what can be done? Assess Eval High Educ. 2008;33:301–314. doi:10.1080/02602930701293231
28. Baruch Y, Holtom HB. Survey response rate levels and trends in organizational research. Hum Relat. 2008;61:1139–1160. doi:10.1177/0018726708094863
29. Robertson DP, Keys W, Rautemaa-Richardson R, Burns R, Smith AJ. Management of severe acute dental infection. Br Med J. 2015;350:h1300. doi:10.1136/bmj.h1300
30. Fouad AF. Are antibiotics effective for endodontic pain? Endod Topics. 2002;3:52–66. doi:10.1034/j.1601-1546.2002.30106.x
31. Keiser K, Hargreaves KM. Building effective strategies for the management of endodontic pain. Endod Topics. 2002;3:93–105. doi:10.1034/j.1601-1546.2002.30109.x
32. Keenan JV, Farman AG, Fedorowicz Z, Newton JT. A Cochrane systematic review finds no evidence to support the use of antibiotics for pain relief in irreversible pulpitis. J Endod. 2006;32:87–92. doi:10.1016/j.joen.2005.10.029
33. Fedorowicz Z, van Zuuren EJ, Farman AG, Agnihotry A, Al-Langawi JH. Antibiotic use for irreversible pulpitis. Cochrane Libr. 2013;12:CD004969.
34. Agnihotry A, Fedorowicz Z, van Zuuren EJ, Farman AG, Al-Langawi JH. Antibiotic use for irreversible pulpitis. Cochrane Libr. 2019. doi:10.1002/14651858.CD004969.pub5
35. Virdee S, Seymour D, Bhakta S. Effective anesthesia of the acutely inflamed pulp: part 1. The acutely inflamed pulp. Br Dent J. 2015a;219:385–390. doi:10.1038/sj.bdj.2015.812
36. Virdee S, Bhakta S, Seymour D. Effective anesthesia of the acutely inflamed pulp: part 2. Clinical strategies. Br Dent J. 2015b;219:439–445. doi:10.1038/sj.bdj.2015.843
37. Bergenholtz G, Hörsted-Bindslev P, Reit C. Textbook of Endodontology.
38. Kelley K, Clark B, Brown V, Sitzia J. Good practice in the conduct and reporting of survey research. Int J Qual Health C. 2003;15:261–266. doi:10.1093/intqhc/mzg031
39. Fricker RD, Schonlau M. Advantages and disadvantages of Internet research surveys: evidence from the literature. Field Methods. 2002;14:347–367. doi:10.1177/152582202237725
40. Heiervang E, Goodman R. Advantages and limitations of web-based surveys: evidence from a child mental health survey. Soc Psychiatry Psychiatr Epidemiol. 2011;46:69–76. doi:10.1007/s00127-009-0171-9